|
KMID : 0379520090250030140
|
|
한국독성학회지
2009 Volume.25 No. 3 p.140 ~ p.146
|
|
|
28-Day Oral Toxicity of Cadmium Selenide in Sprague-Dawley Rats
|
|
Kim Yong-Soon
Song Moon-Yong
Kim Jin-Sik
Rha Dea-Sik
Jeon Yong-Joon
Kim Ji-Eun
Ryu Hyeon-Yeol
Yu Il-Je
Song Kyung-Seuk
|
|
|
Abstract
|
|
|
|
This study was performed to evaluate the toxicity of cadmium selenide for a period of 28 days in Sprague-Dawley rats. Each of 10 healthy male and females rats per group received daily oral administration for 28-day period at dosage levels 30, 300 and 1,000 ㎎/㎏ of body weight. Mortality and clinical signs were checked, and body weight, water intake and food consumption were also recorded weekly. There were no dose-related changes in food consumption or urine volume. All animals survived to the end of study with no clinical signs or differences in body weight gain observed when compared with the control group. At the end of study, all animals including control group, were subjected to necropsy. Blood samples were collected for hematology tests including coagulation time and biochemistry analysis. Blood coagulation time and relative organ weight were unaffected by all received doses. White Blood Cell (WBC) counts significantly increased in the 300 ㎎/㎏ administered male animal group when compared to the control. Monocyte (MO) value were also increased significantly in both 300 and 1,000 ㎎/㎏ male animal group. However, Mean Corpuscular Volume (MCV) were significantly decreased compared with the control in the 1,000 ㎎/㎏ dose groups for male and female animals. Mean Corpuscular Hemoglobin (MCH) decreased significantly for female in the 300 and 1,000 ㎎/㎏ group compared to the control. Blood biochemical values of Inorganic phosphorus (IP) were significantly increased in both the 300 and 1,000 ㎎/㎏ dose groups in male animals when compared to the control. Creatinine (CRE) levels indicated significant increase in kidney function for the female, 30 ㎎/㎏ dose group when compared with control. There was a significant decrease in thymus absolute organ weight in the female, 1,000 ㎎/㎏ dose group when compared with control. Histopathological findings revealed no evidence of injury related to cadmium selenide except for one case of focal hepatic inflammation in the high dose (1,000 ㎎/㎏) group. One case of lung inflammation was also seen in the control group. Basis on these result, the No Observable Adverse Effect Level (NOAEL) of cadmium selenide was determined to be more than 1,000 mg/kg/day for male and female rats under conditions in this study.
|
|
|
KEYWORD
|
|
|
28-Oral administration, Toxicology, Cadmium selenide, Rat, ISO 10993-11
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|